2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126381
    Boc-N-PEG5-C2-NHS ester 2055040-78-1
    Boc-N-PEG5-C2-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-N-PEG5-C2-NHS ester
  • HY-140618
    DNP-PEG4-alcohol 1807520-99-5 98.71%
    DNP-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DNP-PEG4-alcohol
  • HY-133495
    Folate-PEG2-amine 1099829-15-8
    Folate-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Folate-PEG2-amine
  • HY-141198
    Boc-NH-PEG2-NH-Boc 475591-59-4
    Boc-NH-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-NH-Boc
  • HY-140442
    Fmoc-aminooxy-PEG12-NHS ester
    Fmoc-aminooxy-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-aminooxy-PEG12-NHS ester
  • HY-132070
    FA-PEG5-Mal 99.46%
    FA-PEG5-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    FA-PEG5-Mal
  • HY-140038
    Bis-propargyl-PEG1 40842-04-4 98.0%
    Bis-propargyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-propargyl-PEG1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG1
  • HY-140793
    Azido-PEG2-C1-Boc 251564-45-1
    Azido-PEG2-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C1-Boc
  • HY-22393
    Diethylene Glycol Monobenzyl Ether 2050-25-1 99.37%
    Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Diethylene Glycol Monobenzyl Ether
  • HY-W096162
    NH2-PEG2-methyl acetate 741235-80-3
    NH2-PEG2-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG2-methyl acetate
  • HY-140548
    NH-bis-PEG4 63721-14-2 98.0%
    NH-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis-PEG4
  • HY-147205A
    Biotin-PEG-OH (MW 2000)
    Biotin-PEG-OH (MW 2000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG-OH (MW 2000)
  • HY-W096078
    Bromo-PEG7-azide 1056969-61-9
    Bromo-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG7-azide
  • HY-140955
    DSPE-PEG4-DBCO 2112738-14-2
    DSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DSPE-PEG4-DBCO
  • HY-140975
    Mal-amido-PEG24-acid 2171095-70-6 98.51%
    Mal-amido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG24-acid
  • HY-140254
    N-(Amino-PEG3)-N-bis(PEG4-Boc) 2353409-57-9 98.0%
    N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Amino-PEG3)-N-bis(PEG4-Boc)
  • HY-133193
    Bis-propargyl-PEG5 185378-83-0 98.0%
    Bis-propargyl-PEG5 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG5 is used for the synthesis of carbohydrate receptors (SCRs) with anti-Zika activity. Bis-propargyl-PEG5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG5
  • HY-140566
    N-Azido-PEG4-N-Boc-N-PEG3-Boc 2093152-85-1
    N-Azido-PEG4-N-Boc-N-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Azido-PEG4-N-Boc-N-PEG3-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-Azido-PEG4-N-Boc-N-PEG3-Boc
  • HY-130560
    Biotin-PEG3-propionic hydrazide 1381861-94-4
    Biotin-PEG3-propionic hydrazide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG3-propionic hydrazide
  • HY-130554
    m-PEG9-phosphonic acid 2055016-25-4 99.33%
    m-PEG9-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG9-phosphonic acid
PROTAC Linkers Isoform Comparison

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